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Cysmic was born from a group of scientists with a strong background in red blood cell physiology, pathophysiology, biophysics, rare anemias, microfluidics, microscopy, hardware and software development, and AI.
Below is a list of our most recent blood research-related peer-reviewed publications:
  • Recktenwald, S.M., G. Simionato, M.G. Lopes, F. Gamboni, M. Dzieciatkowska, P. Meybohm, K. Zacharowski, A. von Knethen, C. Wagner, L. Kaestner, A. D’Alessandro, and S. Quint. 2022. Cross-talk between red blood cells and plasma influences blood flow and omics phenotypes in severe COVID-19. Elife. 11:1–17. doi:

  • Recktenwald, S.M., M.G.M. Lopes, S. Peter, S. Hof, G. Simionato, K. Peikert, A. Hermann, A. Danek, K. van Bentum, H. Eichler, C. Wagner, S. Quint, and L. Kaestner. 2022. Erysense, a Lab-on-a-Chip-Based Point-of-Care Device to Evaluate Red Blood Cell Flow Properties With Multiple Clinical Applications. Front. Physiol. 13:1–10. doi: 10.3389/fphys.2022.884690.
  • Recktenwald, S.M., K. Graessel, F.M. Maurer, T. John, S. Gekle, and C. Wagner. 2022. Red blood cell shape transitions and dynamics in time-dependent capillary flows. Biophys. J. 121:23–36. doi: 10.1016/j.bpj.2021.12.009.
  • Minetti, G., A.Y. Bogdanova, H. Mairbäurl, and L. Kaestner. 2022. Space anemia unexplained: Red blood cells seem to be space‐proof. Am. J. Hematol. doi: 10.1002/ajh.26663.
  • Kaestner, L. 2022. Artificial intelligence: Training the trainer. Br. J. Haematol. 1–2. doi: 10.1111/bjh.18358.
  • Rabe, A., A. Kihm, A. Darras, K. Peikert, G. Simionato, A.K. Dasanna, H. Glaß, J. Geisel, S. Quint, A. Danek, C. Wagner, D.A. Fedosov, A. Hermann, and L. Kaestner. 2021. The Erythrocyte Sedimentation Rate and Its Relation to Cell Shape and Rigidity of Red Blood Cells from Chorea-Acanthocytosis Patients in an Off-Label Treatment with Dasatinib. Biomolecules. 11:727. doi: 10.3390/biom11050727.
  • Simionato, G., K. Hinkelmann, R. Chachanidze, P. Bianchi, E. Fermo, R. van Wijk, M. Leonetti, C. Wagner, L. Kaestner, and S. Quint. 2021. Red blood cell phenotyping from 3D confocal images using artificial neural networks. PLOS Comput. Biol. 17:e1008934. doi: 10.1371/journal.pcbi.1008934. doi: 10.1371/journal.pcbi.1008934.
  • Martin-Wortham, J., S.M. Recktenwald, M.G.M. Lopes, L. Kaestner, C. Wagner, and S. Quint. 2021. A deep learning-based concept for high throughput image flow cytometry. Appl. Phys. Lett. 118:123701. doi: 10.1063/5.0037336.
  • Kihm, A., S. Quint, M.W. Laschke, M.D. Menger, T. John, L. Kaestner, and C. Wagner. 2021. Lingering Dynamics in Microvascular Blood Flow. Biophys. J. 120:432–439. doi: 10.1016/j.bpj.2020.12.012.
  • Simionato, G., R. van Wijk, S. Quint, C. Wagner, P. Bianchi, and L. Kaestner. 2021. Rare Anemias: Are Their Names Just Smoke and Mirrors? Front. Physiol. 12:1–5. doi: 10.3389/fphys.2021.690604.
  • Abay, A., S.M. Recktenwald, T. John, L. Kaestner, and C. Wagner. 2020. Cross-sectional focusing of red blood cells in a constricted microfluidic channel. Soft Matter. 16:534–543. doi: 10.1039/C9SM01740B.
  • Huisjes, R., A. Makhro, E. Llaudet-Planas, L. Hertz, P. Petkova-Kirova, L.P. Verhagen, S. Pignatelli, M.A.E. Rab, R.M. Schiffelers, E. Seiler, W.W. van Solinge, J.-Ll.V. Corrons, L. Kaestner, M. Mañú-Pereira, A. Bogdanova, and R. van Wijk. 2020. Density, heterogeneity and deformability of red cells as markers of clinical severity in hereditary spherocytosis. Haematologica. 105:338–347. doi: 10.3324/haematol.2018.188151.
  • Mahkro, A., I. Hegemann, E. Seiler, G. Simionato, V. Claveria, N. Bogdanov, C. Sasselli, P. Torgerson, L. Kaestner, M.G. Manz, J.S. Goede, M. Gassmann, and A. Bogdanova. 2020. A pilot clinical phase II trial MemSID: Acute and durable changes of red blood cells of sickle cell disease patients on memantine treatment. eJHaem. 1:23–34.  doi: 10.1002/jha2.11.
  • Bogdanova, A., L. Kaestner, G. Simionato, A. Wickrema, and A. Makhro. 2020. Heterogeneity of Red Blood Cells: Causes and Consequences. Front. Physiol. 11:1–11. doi: 10.3389/fphys.2020.00392.
  • Abay, A., G. Simionato, R. Chachanidze, A. Bogdanova, L. Hertz, P. Bianchi, E. van den Akker, M. von Lindern, M. Leonetti, G. Minetti, C. Wagner, and L. Kaestner. 2019. Glutaraldehyde – A Subtle Tool in the Investigation of Healthy and Pathologic Red Blood Cells. Front. Physiol. 10:1–14. doi: 10.3389/fphys.2019.00514.
  • Petkova-Kirova, P., L. Hertz, J. Danielczok, R. Huisjes, A. Makhro, A. Bogdanova, M. del M. Mañú-Pereira, J.-L. Vives Corrons, R. van Wijk, and L. Kaestner. 2019. Red Blood Cell Membrane Conductance in Hereditary Haemolytic Anaemias. Front. Physiol. 10:1–17. doi: 10.3389/fphys.2019.00386.
  • Bernhardt, I., M. C. Wesseling, D.B. Nguyen, and L. Kaestner. 2019. Red Blood Cells Actively Contribute to Blood Coagulation and Thrombus Formation. In: Erythrocyte. IntechOpen. doi: 10.5772/intechopen.86152.
  • Quint, S., A.F. Christ, A. Guckenberger, S. Himbert, L. Kaestner, S. Gekle, and C. Wagner. 2017. 3D tomography of cells in micro-channels. Appl. Phys. Lett. 111:1–5. doi: 10.1063/1.4986392.


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